"Instead of taking the obvious route...Off Label adopts an elliptical strategy that proves as effective as it is unexpected" Los Angeles Times
"Tragicomically beautiful... sensitively favors unflinching testimonials and visually impressionistic observations over journalistic activism" Village Voice
By some distance, Americans are the most medicated nation in the world. With every one of the thousands of drugs on the market needing to be heavily tested, an entire subculture exists of desperate people who allow themselves to be used as human guinea pigs.
Filmmakers Michael Palmieri and Donal Mosher (October Country) provide a powerful and disquieting focus on a side of America we seldom see. They introduce us to a range of people who have repeatedly took part in drugs trials for cash. They are in the medicated margins of American society who have gone "off-label"a term that refers to the use of pharmaceuticals in any way counter to their prescribed dosage or function. From these and other interwoven stories, a tragic and bleakly comic look at life, health, and faith in the Twilight Zone of American pharmaceuticals emerges. Welcome to the strange pharmacy that is America, in this provocative exploration of a market-driven, ethics-free US drugs industry.
Directed by Donal Mosher and Michael Palmieri, 2012, U.S.A., 80 mins.